Coronary heart disease mortality in severe vs. non-severe familial hypercholesterolaemia in the Simon Broome Register (2019)

Type of publication:
Journal article

Author(s):
Humphries, Steve E; Cooper, Jackie A; *Capps, Nigel; Durrington, Paul N; Jones, Ben; McDowell, Ian F W; Soran, Handrean; Neil, Andrew H W; Simon Broome Familial Hyperlipidaemia Register Group

Citation:
Atherosclerosis. 2019 Feb;281:207-212

Abstract:
BACKGROUND AND AIMS The International Atherosclerosis Society (IAS) has proposed that patients with "severe" FH (SFH) would warrant early and more aggressive cholesterol-lowering treatment such as with PCSK9 inhibitors. SFH is diagnosed if LDL-cholesterol (LDLC)>10mmol/L, or LDLC >8.0mmol/L plus one highrisk feature, or LDLC >5mmol/L plus two high-risk features. Here we compare CHD mortality in SFH and nonSFH (NSFH) patients in the UK prospective Simon Broome Register since 1991, when statin use became routine.METHODS 2929 definite or possible PFH patients (51% women) aged 20-79 years were recruited from 21 UK lipid clinics and followed prospectively between 1992 and 2016. The excess CHD standardised mortality ratio (SMR) compared to the England and Wales population was calculated (with 95% confidence intervals).RESULTS1982 (67.7%) patients met the SFH definition. Compared to the non-SFH, significantly (p < 0.001) more SFH patients had diagnosed CHD at baseline (24.6% vs. 17.5%), were current smokers (21.9% vs 10.2%) and had a BMI>30kg/m2 (14.9% vs. 7.8%). The SMR for CHD mortality was significantly (p=0.007) higher for SFH (220 (184-261) (34,134 person years, 129 deaths observed, vs. 59 expected) compared to NSFH of 144 (98-203) (15,432 person years, 32 observed vs. 22 expected). After adjustment for traditional risk factors, the Hazard Ratio for CHD mortality in SFH vs. NSFH was 1.22 (0.80-1.87) p=0.36, indicating that the excess risk was largely accounted for by these factors.CONCLUSIONS CHD mortality remains elevated in treated FH, especially for SFH, emphasising the importance of optimal lipid-lowering and management of other risk factors.

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Self-inflicted bilateral ocular and eyelid injuries in an unsuspected individual (2019)

Type of publication:
Journal article

Author(s):
*Samia-Aly, Emma; *Ha, Jerome; *Sagili, Suresh

Citation:
Scottish medical journal; May 2019; vol. 64 (no. 2); p. 78-82

Abstract:
BACKGROUND AND AIMS This report aims to illustrate a case of self-inflicted ocular and orbital injury, resulting in severe tissue loss and ophthalmoplegia in a patient with no known history of mental illness.METHODS AND RESULTS A 71-year-old male initially presented to the emergency department with significant tissue loss from his left upper and lower lids, orbital tissue loss and complete ophthalmoplegia, after reportedly tripping and falling onto his desk. He subsequently attended the emergency department on two further occasions with similar injuries, affecting the same and contralateral eye, whilst maintaining a traumatic cause for his injuries. He was eventually admitted to a psychiatric ward for mental health assessment. This report covers his progress as well as illustrating his injuries with images. CONCLUSION Self-harm is an important differential diagnosis in cases where the mechanism of injury does not correspond to the extent of injury or tissue loss. It can, however, be difficult to differentiate from accidental injury and even with repeated assessments, a formal psychiatric diagnosis may not be possible.

Critical care usage after major gastrointestinal and liver surgery: a prospective, multicentre observational study (2019)

Type of publication:
Journal article

Author(s):
Claireaux H.A.; Antoniou I.; Dean R.; Davies N.; Trecarten S.; Henderson I.; Holmes C.; Wylie J.; Shuttleworth R.H.; Jindal A.; Hughes F.; Gouda P.; McNamee L.; Fleck R.; Hanrahan M.; Karunakaran P.; Chen J.H.; Sykes M.C.; Sethi R.K.; Suresh S.; Patel P.; Patel M.; Varma R.K.; Mushtaq J.; Gundogan B.; Bolton W.; Mohan M.; Khan T.; Burke J.; Morley R.; Favero N.; Adams R.; Thirumal V.; Kennedy E.D.; Ong K.K.; Tan Y.H.; Gabriel J.; Bakhsh A.; Low J.Y.L.; Yener A.; Paraoan V.; Preece R.; Tilston T.W.; Cumber E.; Dean S.; Ross T.; McCance E.; Amin H.; Satterthwaite L.; Clement K.D.; Gratton R.; Mills E.D.; Chiu S.M.; Hung G.; Rafiq N.M.; Hayes J.D.B.; Robertson K.L.; Dynes K.; Huang H.C.; Assadullah S.; Duncumb J.W.; Moon R.D.C.; Poo S.X.; Mehta J.K.; Joshi K.R.; Callan R.; Norris J.M.; Chilvers N.J.; Keevil H.; Jull P.; Mallick S.; Elf D.; Carr L.; Player C.; Barton E.C.; Martin A.L.; Ratu S.G.; Roberts E.J.; Phan P.N.; Dyal A.R.; Rogers J.E.; Henson A.D.; Reid N.B.; Burke D.; Culleton G.; Lynne S.; Mansoor S.; Brennan C.; Blessed R.; Holloway C.; Hill A.; Goldsmith T.; Mackin S.; Kim S.; Woin E.; Brent G.; Coffin J.; Ziff O.; Momoh Z.; Debenham R.; Ahmed M.; Yong C.S.; Wan J.C.; Copley H.C.; Raut P.; Chaudhry F.I.; Nixon G.; Dorman C.; Tan R.; Kanabar S.; Canning N.; Dolaghan M.; Bell N.; McMenamin M.; Chhabra A.; Duke K.; Turner L.; Patel T.; Chew L.S.; Mirza M.; Lunawat S.; Oremule B.; Ward N.; Khan M.; Tan E.T.; Maclennan D.; McGregor R.J.; Chisholm E.G.; Griffin E.J.; Bell L.; Hughes B.A.; Davies J.; Haq H.; Ahmed H.; Ungcharoen N.; Whacha C.; Thethi R.; Markham R.M.; Lee A.H.Y.; Batt E.; Bullock N.P.; Francescon C.T.; Davies J.E.; Shafiq N.M.; Zhao J.; Vivekanantham S.; Barai I.; Allen J.L.Y.; Marshall D.C.; McIntyre C.J.; Wilson H.C.P.; Ashton A.J.; Lek C.; Behar N.; Davis-Hall M.; Seneviratne N.; Esteve L.; Sirakaya M.; Ali S.; Pope S.; Ahn J.S.; Craig-McQuaide A.; Gatfield W.A.; Leong S.; Demetri A.M.; Kerr A.L.; Rees C.; Loveday J.; Liu S.; Wijesekera M.; Maru D.; Attalla M.; Smith N.; Brown D.; Sritharan P.; Shah A.; Charavanamuttu V.; Heppenstall-Harris G.; Ng K.; Raghvani T.; Rajan N.; Hulley K.; Moody N.; Williams M.; Cotton A.; Sharifpour M.; Lwin K.N.; Bright M.; Chitnis A.R.; Abdelhadi M.; Semana A.D.; Morgan F.; Reid R.; Dickson J.; Anderson L.; McMullan R.; Ahern N.; Asmadi A.; Anderson L.B.; Boon Xuan J.L.; Crozier L.; McAleer S.; Lees D.M.; Adebayo A.A.; Das M.; Amphlett A.H.; Al-Robeye A.; Valli A.; Khangura J.; Winarski A.; Ali A.; Woodward H.; Gouldthrope C.; Turner M.; Sasapu K.; Tonkins M.; Wild J.R.L.; Robinson M.; Hardie J.; Heminway R.; Narramore R.; Ramjeeawon N.; Hibberd A.; Winslow F.; Ho W.; Chong B.F.; Lim K.; Ho S.; Crewdson J.A.; Singagireson S.; Kalra N.; Koumpa F.; Jhala H.; Soon W.C.; Karia M.; Rasiah M.G.; Xylas D.; Gilbert H.; Sundar-Singh M.; Wills J.; Akhtar S.; Patel S.; Hu L.; Brathwaite-Shirley C.; Nayee H.; Amin O.; Rangan T.; Turner E.J.H.; McCrann C.; Shepherd R.; Patel N.; Prest-Smith J.; Auyoung E.; Murtaza A.; Coates A.; Prys-Jones O.; King M.; Gaffney S.; Dewdney C.J.; Nehikhare I.; Lavery J.; Bassett J.; Davies K.; Ahmad K.; Collins A.; Acres M.; Egerton C.; Cheng K.; Chen X.; Chan N.; Sheldon A.; Khan S.; Empey J.; Ingram E.; Malik A.; Johnstone M.; Goodier R.; Shah J.P.; Giles J.E.; Sanders J.A.; McLure S.W.; Pal S.; Rangedara A.; Baker A.N.; Asbjoernsen C.A.; Girling C.; Gray L.; Gauntlett L.; Joyner C.; Qureshi S.; Mogan Y.P.; Ng J.C.K.; Kumar A.N.; Park J.H.; Tan D.; Choo K.P.; Raman K.P.; Buakuma P.; Xiao C.; Govinden S.; Thompson O.D.; Charalambos M.A.; Brown E.; Karsan R.B.; Dogra T.; Bullman L.M.; Dawson P.M.; Frank A.L.; Abid H.; Tung L.; Qureshi U.; Tahmina A.; Matthews B.W.; Harris R.T.; O'Connor A.; Mazan K.; Iqbal S.; Stanger S.A.; Thompson J.D.; Sullivan J.A.L.; Uppal E.; MacAskill A.; Bamgbose F.A.; Neophytou C.; Carroll A.F.; Rookes C.W.; Datta U.; Dhutia A.J.; Rashid S.; Ahmed N.; Lo T.; Bhanderi S.; Blore C.D.; Ahmed S.; Shaheen H.; Abburu S.; Majid S.; Abbas Z.; Talukdar S.S.; Burney L.J.; Patel J.B.; Al-Obaedi O.; Roberts A.W.; Mahboob S.; Singh B.; Sheth S.; Karia P.; Prabhudesai A.; Kow K.; Koysombat K.; Wang S.; Morrison P.; Maheswaran Y.; Keane P.; Copley P.C.; Brewster O.; Xu G.X.; Harries P.; Wall C.; AlMousawi A.; Bonsu S.; Cunha P.; Ward T.; Paul J.; Nadanakumaran K.; Tayeh S.; Holyoak H.; Remedios J.; Theodoropoulou K.; Luhishi A.; Jacob L.; Long F.; Atayi A.; Sarwar S.; Parker O.; Harvey J.; Ross H.; Rampal R.; Thomas G.; Vanmali P.; McGowan C.; Stein J.; Robertson V.; Carthew L.; Teng V.; Fong J.; Street A.N.; Thakker C.E.; O'Reilly D.; Bravo M.; Pizzolato A.; Khokhar H.A.; Ryan M.; Cheskes L.; Carr R.; Salih A.E.; Bassiony S.; Yuen R.; Chrastek D.; Rosen O'Sullivan H.; Amajuoyi A.; Wang A.; Sitta O.; Wye J.; Qamar M.A.; Major C.; Kaushal A.; Morgan C.; Petrarca M.; Allot R.; Verma K.; Dutt S.; Chilima C.P.; Peroos S.; Kosasih S.R.; Chin H.; Ashken L.; Pearse R.J.; O'Loughlin R.A.; Menon A.; Singh K.; Norton J.; Sagar R.; Jathanna N.; Rothwell L.; Watson N.; Harding F.; Dube P.; Khalid H.; Punjabi N.; Sagmeister M.; Gill P.; Shahid S.; Hudson-Phillips S.; George D.; Ashwood J.; Lewis T.; Dhar M.; Sangal P.; Rhema I.A.; Kotecha D.; Afzal Z.; Syeed J.A.; Prakash E.; Jalota P.; Herron J.; Kimani L.; Delport A.; Shukla A.; Agarwal V.; Parthiban S.; Thakur H.; Cymes W.; Rinkoff S.; Turnbull J.A.; Hayat M.; Darr S.; Khan U.; Lim J.; Higgins A.; Lakshmipathy G.; Forte B.; Canning E.; Jaitley A.; Lamont J.; Toner E.; Ghaffar A.; McDowell M.; Salmon D.; O'Carroll O.; Khan A.; Kelly M.E.; Clesham K.; Palmer C.; Lyons R.; Bell A.; Chin R.; Waldron R.M.; Trimble A.; Cox S.E.; Ashfaq U.; Campbell J.; Holliday R.B.S.; McCabe G.; Morris F.; Priestland R.; Vernon O.K.; Ledsam A.; Vaughan R.; Lim D.; Bakewell Z.R.; Hughes R.K.; Koshy R.M.; Jackson H.R.; Narayan P.; Cardwell A.E.; Jubainville C.L.; Arif T.; Elliott L.E.; Gupta V.; Bhaskaran G.; Odeleye A.; Ahmed F.; Shah R.; Pickard J.; Suleman Y.N.; North A.S.; McClymont L.F.; Hussain N.; Ibrahim I.; Ng G.S.; Wong V.; Lim A.E.; Harris L.N.; Tharmachandirar T.; Mittapalli D.; Patel V.; Lakhani M.; Bazeer H.Z.; Narwani V.; Sandhu K.K.; Wingfield L.R.; Gentry S.; Adjei H.; Bhatti M.; Braganza L.; Barnes J.; Mistry S.; Chillarge G.; Stokes S.; Cleere J.; Wadanamby S.; Bucko A.M.; Meek J.; Boxall N.; Heywood E.G.; Wiltshire J.J.; Toh C.; Ward A.E.; Shurovi B.N.; Horth D.; Patel B.Y.; Ali B.; Spencer T.; Axelson T.; Kretzmer L.; Chhina C.; Anandarajah C.; Fautz T.; Horst C.; Thevathasan A.A.; Ng J.Q.; Hirst F.; Brewer C.F.; Logan A.E.; Lockey J.W.; Forrest P.R.; Keelty N.; Wood A.D.; Springford L.R.; Avery P.; Schulz T.M.; Bemand T.P.; Howells L.; Collier H.; Khajuria A.; Tharakan R.G.; Parsons S.; Buchan A.M.; McGalliard R.J.; Mason J.D.; Cundy O.J.; Li N.; Redgrave N.A.; Watson R.P.; Pezas T.P.; Dennis Y.F.; Segall E.; Hameed M.; Lynch A.S.; Chamberlain M.; Peck F.S.; Neo Y.N.; Russell G.; Elseedawy M.; Lee S.; Foster N.L.; Soo Y.H.; Puan L.; Dennis R.; Goradia H.; Qureshi A.; Osman S.; Reeves T.; Dinsmore L.; Marsden M.; Lu Q.; Pitts-Tucker T.; Dunn C.E.; Walford R.A.; Heathcote E.; Martin R.; Pericleous A.; Brzyska K.; Reid K.G.; Williams M.R.; Wetherall N.; McAleer E.; Thomas D.; Kiff R.; Milne S.; Holmes M.J.V.; Bartlett J.; Lucas de Carvalho J.; Bloomfield T.; Tongo F.; Bremner R.H.; Yong N.; Atraszkiewicz B.A.; Mehdi A.; Tahir M.; Sherliker G.X.J.; Tear A.K.; Pandey A.; Broyd A.; Omer H.M.; Raphael M.; Chaudhry W.W.; Shahidi S.; Jawad A.S.; Gill C.K.; Fisher I.H.; Adeleja I.; Clark I.J.; Aidoo-Micah G.E.; Stather P.W.; Salam G.J.; Glover T.E.; Deas G.; Sim N.K.; Obute R.D.; Wynell-Mayow W.M.; Sait M.S.; Mitha N.; de Bernier G.L.; Siddiqui M.; Shaunak R.; Wali A.; Cuthbert G.; Bhudia R.; Webb E.; Shah S.; Ansari N.; Perera M.; Kelly N.; McAllister R.; Stanley G.H.; Keane C.P.; Shatkar V.; MaxwellArmstrong C.; Henderson L.A.; Maple N.; Manson R.; Adams R.D.; Semple E.; Mills M.; Daoub A.; Marsh A.; Ramnarine A.; Hartley J.; Malaj M.; Jewell P.D.; Whatling E.A.; Hitchen N.; Chen M.; Goh B.; Fern J.; Rogers S.; Derbyshire L.; Robertson D.T.; Abuhussein N.; Deekonda P.; Abid A.; Harrison P.L.M.; Aildasani L.; Turley H.; Sherif M.A.; Pandey G.; Filby J.J.; Johnston A.; Burke E.; Mohamud M.; Gohil K.; Tsui A.Y.; Singh R.; Lim S.J.; O'Sullivan K.; McKelvey L.L.; O'Neill S.; Roberts H.F.; Brown F.S.; Cao Y.; Buckle R.T.; Liew Y.; Sii S.; Ventre C.M.; Graham C.J.; Filipescu T.; Yousif A.; Dawar R.; Wright A.; Peters M.; Varley R.; Owczarek S.; Hartley S.; Khattak M.; Iqbal A.; Ali M.; Durrani B.; Narang Y.; Bethell G.S.; Horne L.; Pinto R.; Nicholls K.; Kisyov I.; Torrance H.D.; English W.; Lakhani S.M.; Ashraf S.F.; Venn M.; Elangovan V.; Kazmi Z.; Brecher J.; Sukumar S.; Mastan A.; Mortimer A.; Parker J.; Boyle J.; Elkawafi M.; *Beckett J.; *Mohite A.; *Narain A.; *Mazumdar E.; *Sreh A.; *Hague A.; *Weinberg D.; *Fletcher L.; *Steel M.; Shufflebotham H.; Masood M.; Sinha Y.; Jenvey C.; Kitt H.; Slade R.; Craig A.R.; Deall C.; Reakes T.; Chervenkoff J.; Strange E.; O'Bryan M.; Murkin C.; Joshi D.; Bergara T.; Naqib S.; Wylam D.; Scotcher S.E.; Hewitt C.M.; Stoddart M.T.; Kerai A.; Trist A.J.; Cole S.J.; Knight C.L.; Stevens S.; Cooper G.E.; Ingham R.; Dobson J.; O'Kane A.; Moradzadeh J.; Duffy A.; Henderson C.; Ashraf S.; McLaughin C.; Hoskins T.C.; Reehal R.S.; Bookless L.R.; McLean R.C.; Stone E.J.; Wright E.V.; Abdikadir H.R.; Roberts C.; Spence O.; Srikantharajah M.; Ruiz E.M.; Matthews J.H.; Gardner E.; Hester E.; Naran P.; Simpson R.; Minhas M.; Cornish E.; Semnani S.A.; Rojoa D.; Radotra A.; Eraifej J.; Eparh K.; Smith D.N.E.; Mistry B.D.; Hickling S.L.; Din W.; Liu C.; Mithrakumar P.; Mirdavoudi V.; Rashid M.; Mcgenity C.; Hussain O.; Kadicheeni M.; Gardner H.; Anim-Addo N.; Pearce J.; Aslanyan A.; Ntala C.; Sorah T.; Parkin J.; Alizadeh M.; White A.; Edozie F.; Johnston J.; Kahar A.; Navayogaarajah V.; Patel B.; Carter D.; Khonsari P.; Burgess A.; Kong C.; Ponweera A.; Cody A.; Tan Y.; Ng A.Y.L.; Croall A.; Allan C.; Ng S.; Raghuvir V.; Telfer R.; Greenhalgh A.D.; McKerr C.N.; Edison M.A.; Patel B.A.; Dear K.; Hardy M.R.; Williams P.; Hassan S.; Sajjad U.; O'Neill E.M.; Lopes S.; Healy L.; Jamal N.; Tan S.; Lazenby D.; Husnoo S.B.; Beecroft S.; Sarvanandan T.; Weston C.; Bassam N.; Rabinthiran S.; Hayat U.; Ng L.; Varma D.; Sukkari M.; Mian A.; Omar A.; Kim J.W.; Sellathurai J.; Mahmood J.; O'Connell C.; Bose R.; Heneghan H.; Lalor P.; Matheson J.; Doherty C.; Cullen C.; Cooper D.; Angelov S.; Drislane C.; Smith A.C.D.; Kreibich A.; Palkhi E.; Durr A.; Lotfallah A.; Gold D.; Mckean E.; Dhanji A.; Anilkumar A.; Thacoor A.; Siddiqui Z.H.; Lim S.; Piquet A.; Anderson S.M.; McCormack D.R.; Gulati J.; Ibrahim A.; Murray S.E.; Walsh S.L.; McGrath A.; Ziprin P.; Chua E.Y.; Lou C.N.; Bloomer J.; Paine H.R.; Osei-Kuffour D.; White C.J.; Szczap A.; Gokani S.; Patel K.; Malys M.K.; Reed A.; Torlot G.E.; Cumber E.M.; Charania A.; Ahmad S.; Varma N.; Cheema H.; Austreng L.; Petra H.; Chaudhary M.; Zegeye M.I.; Cheung F.; Coffey D.; Heer R.S.; Singh S.; Seager E.; Cumming S.; Suresh R.S.; Verma S.; Ptacek I.B.; Gwozdz A.M.; Yang T.; Khetarpal A.A.; Shumon S.; Fung T.M.P.; Leung W.; Kwang P.; Chew L.; Loke W.; Curran A.; Chan C.; McGarrigle C.; Mohan K.; Cullen S.; Wong E.; Toale C.; Collins D.; Keane N.; Traynor B.P.; Shanahan D.; Yan A.; Jafree D.J.; Topham C.; Mitrasinovic S.; Omara S.; Bingham G.; Lykoudis P.M.; Miranda B.H.; Whitehurst K.; Kumaran G.; Devabalan Y.; Aziz H.; Shoa M.; Dindyal S.; Yates J.A.; Bernstein I.; Rattan G.; Coulson R.; Stezaker S.; Isaac A.; Salem M.; McBride A.; McFarlane H.; Yow L.; MacDonald J.; Bartlett R.D.; Turaga S.; White U.; Liew W.; Yim N.; Ang A.; Simpson A.; McAuley D.; Craig E.; Murphy L.; Shepherd P.; Kee J.Y.; Abdulmajid A.; Chung A.; Warwick H.L.; Livesey A.; Holton P.; Theodoreson M.D.; Jenkin S.L.; Turner J.; Entwisle J.H.; Marchal S.T.; O'Connor S.; Blege H.K.; Aithie J.M.; Sabine L.M.; Stewart G.E.; Jackson S.; Kishore A.; Lankage C.M.; Acquaah F.; Joyce H.L.; McKevitt K.L.; Coffey C.J.; Fawaz A.S.; Dolbec K.S.; O'Sullivan D.A.; Geraghty J.M.; Lim E.; Bolton L.; FitzPatrick D.; Robinson C.; Ramtoola T.; Collinson S.; Grundy L.; McEnhill P.M.; Harbhajan Singh G.S.; Loughran D.; Golding D.M.; Keeling R.E.; Williams R.P.; Whitham R.D.J.; Yoganathan S.; Nachiappan R.; Egan R.J.; Owasil R.; Kwan M.L.; He A.; Goh R.W.; Bhome R.; Wilson H.; Teoh P.J.; Raji K.; Jayakody N.; Matthams J.; Chong J.; Luk C.Y.; Greig R.J.; Trail M.; Charalambous G.; Rocke A.S.; Gardiner N.; Bulley F.; Warren N.; Brennan E.; Fergurson P.; Wilson R.; Whittingham H.; Brown E.J.; Khanijau R.; Gandhi K.; Morris S.; Boulton A.J.; Chandan N.; Barthorpe A.E.; Maamari R.; Sandhu S.; McCann M.; Higgs L.; Balian V.; Reeder C.; Diaper C.; Sale T.; Ali H.; Archer C.H.; Clarke A.K.; Heskin J.; Hurst P.C.; Farmer J.D.; O'Flynn L.D.; Doan L.; Shuker B.A.; Stott G.D.; Vithanage N.A.; Hoban K.A.; Nesargikar P.N.; Kennedy H.R.; Grossart C.M.; Tan E.S.M.; Roy C.S.D.; Sim P.; Leslie K.E.; Sim D.; Abul M.H.; Cody N.; Tay A.Y.; Woon E.; Sng S.; Mah J.; Robson J.; Shakweh E.; Wing V.C.; Mills H.; Li M.M.; Barrow T.R.; Balaji S.; Jordan H.E.M.; Phillips C.; Naveed H.; Hirani S.; Tai A.; Ratnakumaran R.; Sahathevan A.; Shafi A.M.A.; Seedat M.; Weaver R.; Batho A.; Punj R.; Selvachandran H.; Bhatt N.; Botchey S.; Khonat Z.; Brennan K.; Morrison C.J.; Devlin E.; Linton A.; Galloway E.; McGarvie S.; Ramsay N.; McRobbie H.D.; Whewell H.; Dean W.; Nelaj S.; Eragat M.; Mishra A.; Kane T.; Zuhair M.; Wells M.; Wilkinson D.; Woodcock N.; Sun E.; Aziz N.; Ghaffar M.K.A.; McLean K.A.; Glasbey J.C.; Borakati A.; Brooks T.M.; Chang H.M.; Choi S.M.; Goodson R.; Nielsen M.; Pronin S.; Salloum N.L.; Sewart E.; Vanniasegaram D.; Drake T.M.; Gillies M.A.; Harrison E.M.; Chapman S.J.; Khatri C.; Kong C.Y.; Bath M.F.; Kelly M.; Mitchell H.; Fitzgerald J.E.; Bhangu A.; Nepogodiev D

Citation:
British Journal of Anaesthesia; Jan 2019; vol. 122 (no. 1); p. 42-50

Abstract:
Background: Patient selection for critical care admission must balance patient safety with optimal resource allocation. This study aimed to determine the relationship between critical care admission, and postoperative mortality after abdominal surgery. Method(s): This prespecified secondary analysis of a multicentre, prospective, observational study included consecutive patients enrolled in the DISCOVER study from UK and Republic of Ireland undergoing major gastrointestinal and liver surgery between October and December 2014. The primary outcome was 30-day mortality. Multivariate logistic regression was used to explore associations between critical care admission (planned and unplanned) and mortality, and inter-centre variation in critical care admission after emergency laparotomy. Result(s): Of 4529 patients included, 37.8% (n=1713) underwent planned critical care admissions from theatre Some 3.1% (n=86/2816) admitted to ward-level care subsequently underwent unplanned critical care admission. Overall 30-day mortality was 2.9% (n=133/4519), and the risk-adjusted association between 30-day mortality and critical care admission was higher in unplanned [odds ratio (OR): 8.65, 95% confidence interval (CI): 3.51-19.97) than planned admissions (OR: 2.32, 95% CI: 1.43-3.85). Some 26.7% of patients (n=1210/4529) underwent emergency laparotomies. After adjustment, 49.3% (95% CI: 46.8-51.9%, P<0.001) were predicted to have planned critical care admissions, with 7% (n=10/145) of centres outside the 95% CI. Conclusion(s): After risk adjustment, no 30-day survival benefit was identified for either planned or unplanned postoperative admissions to critical care within this cohort. This likely represents appropriate admission of the highest-risk patients. Planned admissions in selected, intermediate-risk patients may present a strategy to mitigate the risk of unplanned admission. Substantial inter-centre variation exists in planned critical care admissions after emergency laparotomies.

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Patent foramen ovale causing breathlessness and platypnoea-orthodeoxia syndrome in an older patient (2018)

Type of publication:
Journal article

Author(s):
*Madden, Katy; *MacKintosh, Abigail; *Mike, Nigel

Citation:
Age and Ageing; Jan 2019; vol. 48, no. 1, p.157-159

Abstract:
An 82-year-old male presented with a week's history of shortness of breath on exertion, particularly when bending to tie his shoe laces. The breathlessness worsened on standing and was relieved by lying. His oxygen saturations were noted to fluctuate based on position dropping to 82% on standing. This was suggestive of platypnoea-orthodeoxia syndrome (POS), an uncommon but potentially reversible diagnosis. As the population ages we may be more likely to see patients with persisting patent foramen ovale decompensate and develop POS.

Psychosexual outcomes in women of reproductive age at more than two-years from excisional cervical treatment - a cross-sectional study (2019)

Type of publication:
Journal article

Author(s):
Sparić, Radmila; *Papoutsis, Dimitrios; Kadija, Saša; Stefanović, Radomir; *Antonakou, Angeliki; Nejković, Lazar; Kesić, Vesna

Citation:
Journal of Psychosomatic Obstetrics and Gynaecology; Apr 2019; vol. 40 (no. 2); p. 128-137

Abstract:
PURPOSE To investigate the long-term psychosexual outcomes in women following excisional cervical treatment. MATERIALS AND METHODS Women with cold-knife conization (CKC) or large loop excision of the transformation zone (LLETZ) treatment were interviewed after a follow-up colposcopy visit. Their demographics, treatment and psychosexual characteristics were recorded. RESULTS One hundred and forty six women with a mean age of 35.2 ± 5.4 years underwent either LLETZ (68.5%) or CKC (31.5%) treatment within 4.7 ± 2.7 years (range: 2-15) before the interview. 27.4% of women were less interested in sexual intercourse following treatment in comparison with their interest before. Those women with less interest in sexual intercourse after treatment had higher anxiety and depression scores and were more worried about disease progression. Women with post-treatment complications were at risk of less interest in sexual intercourse and of greater anxiety and depression. Women with abnormal smears at follow-up were at risk of greater anxiety. The type of treatment and grade of dysplasia did not affect their interest in sexual intercourse or the anxiety and depression scores. CONCLUSIONS Approximately, one-third of women at more than two years posttreatment may suffer from less interest in sexual intercourse, have relatively greater anxiety and depression, and might still be concerned about the possibility of disease progression.